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Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450 2C subfamily
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450 2C subfamily
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机译:人类细胞色素P450 2C亚家族多个成员的互补DNA的克隆和表达
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摘要
The invention provides two novel members of the cytochrome P450 2C subfamily of enzymes, designated 2C18 and 2C19. DNA segments encoding these enzymes are also provided. The 2C19 polypeptide represents the principal human determinant of human S-mephenytoin 4'-hydroxylase activity. The invention also provides methods of identifying drugs metabolized by S-mephenytoin 4'-hydroxylase activity. Drugs shown to be metabolized by this activity should in general not be administered to individuals having, or belong to an ethnic group at risk of, a polymorphic deficiency in S-mephenytoin 4'-hydroxylase activity.
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