Method of increasing viability of stored erythrocytes by addition of lipoic, dihydrolipoic, 6,8-bisnortetralipoic, or tetranorlipoic acid

摘要

A method of improving the properties of liquid stored or cryogenically stored erythrocytes using D,L--lipoic acid and/or enantiomers or derivatives thereof. Treatment with these substances results in improved oxygen release capacity (2,3-DPG), viscoelasticity and erythrocyte aggregability, and increased resistance to membrane peroxidation during storage and damage by the freeze/thaw process.