METHOD OF INCREASING VIABILITY OF STORED ERYTHROCYTES BY ADDITION OF LIPOIC, DIHYDROLIPOIC, 6,8-BISNORTETRALIPOIC OR TETRANORLIPOIC ACID

摘要

In comparison with currently used methods for storing blood, the following advantages could be achieved by the addition according to the invention of D,L-.alpha.-lipoic acid and/or the enantiomers thereof and/or the derivatives thereof before storage: the properties of erythrocyte concentrates at 4°C could be improved with regard to their oxygen release capacity (2,3-DPG) and viscoelasticity and with regard to membrane peroxidation during storage and for subsequent transfusion by means of the above-stated bodily, i.e. physiological substance. The same applies to cryogenically stored erythrocytes which are additionally protected from damage by the freeze/thaw process and the erythrocyte aggregability of which is improved.