INTRACELLULAR CALCIUM INDUCTIVE CALCIUM RELEASE CHANNEL ACTIVITY REGULATOR

摘要

PROBLEM TO BE SOLVED: To obtain a regulator which inhibits the increase of the intracellulor calcium concentration due to the opening of intracellular calcium inductive calcium release channel caused by caffeine and, as a result, is effective in the prevention and the treatment of ischemic heart disease and the like by formulating a specific ellipticine derivative as an active ingredient. ;SOLUTION: This regulator includes an ellipticine derivative with a skeleton of formula I or its pharmacologically permissible salt, suitably an ellipticine derivative of formula II (R is H, a lower alkyl, etc.; R² is H and a lower alkyl) or the like as an active ingredient. It is preferable that the above-stated derivative is 9-hydroxyellipticine or a compound convertible to 9-hydroxyellipticine in vivo. For example, 9-hydroxyellipticine may be reacted with a carboxylic acid derivative in a solvent in the presence of a condensing agent or a deacidification agent and then submitted to the deprotection reaction.;COPYRIGHT: (C)1999,JPO