A pharmaceutical composition comprising a neutralizing activity against type I interferons, monoclonal antibodies against the interferon receptor

摘要

The invention relates to pharmaceutical compositions for use as immunomodulator, comprising a purified preparation of a monoclonal antibody directed against the human interferon class I receptor (IFN-R) characterized by the following properties: it recognizes the extracellular domain of the human IFN-R, and it has a neutralizing capacity against the biological properties of the human type I-IFN. It further concerns their use for the diagnosis.