Use of an agent that interferes in the interaction between the Human topoisomerase I and the HIV Protein for preparing a composition for inhibiting the replication of HIV in cells infected with hiV, a method to identify the test compounds capable of inhibiting HIV Infection and Cell Strain of APP transgenic mouse in said method

摘要

Refers to pharmaceutical compositions and therapeutic Protocols designed to target the Topo I for the treatment of HIV infection.Refers to therapeutic methods and Pharmaceutical compositions for the treatment of HIV infection through the use of Topo I,And refers to its interaction with the FIR gag and RT as a target of intervention. Also refers to the use of Human paraacentuar Topo I activity of RT.Also be Press referring to the expression of the Human Topo I in transgenic animals, including MICE,As a system for studying the life cycle of HIV and to select agents based on their ability to interfere with the life cycle of H IV.