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Process for separation of human DNase human DNase desamidada purified pharmaceutical compositions storage method of human DNase and treatment methods of patient.
Process for separation of human DNase human DNase desamidada purified pharmaceutical compositions storage method of human DNase and treatment methods of patient.
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机译:人脱氧核糖核酸酶的分离方法人脱氧核糖核酸酶纯化的药物组合物的保存方法和患者的治疗方法。
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摘要
The present invention provides the identification and characterization of two components of a recombinant preparation of DNase. These components are the purified deamidated and non-deamidated human DNases. Taught herein are the separation of these components and the use of the non-deamidated species as a pharmaceutical per se, and in particular in compositions wherein the species is disclosed within a plastic vial, for use in administering to patients suffering from pulmonary distress.
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