Eradication of Human Ovarian Cancer Cells by Transgenic Expression of Recombinant DNASE1 DNASE1L3 DNASE2 and DFFB Controlled by EGFR Promoter: Novel Strategy for Targeted Therapy of Cancer

摘要

IntroductionOvarian cancer is the most deadly among all gynecological cancers. Patients undergoing systemic therapies of advanced ovarian cancers suffer from horrendous side effects. Cancer survivors and their offspring suffer from iatrogenic consequences of systemic therapies: genetic mutations. The ultimate goal of our work is development of therapies, which selectively and completely eliminate cancer cells, but do not harm healthy cells. An important consideration for attaining this goal is the fact that ovarian cancer cells over-express EGFR or its mutants, what becomes the factor discriminating them from healthy cells - a potential facilitator of personalized therapy.