Method for separating DNase forms , human DNase, pharmaceutical composition, DNase storage method, treatment method

摘要

The present invention provides the identification and characterization of two components of a recombinant preparation of DNase. These components are the purified deamidated and non-deamidated human DNases. Taught herein are the separation of these components and the use of the non-deamidated species as a pharmaceutical per se, and in particular in compositions wherein the species are disclosed within a plastic vial, for use in administering to patients suffering from pulmonary distress.