Cloning and expression of humanized monoclonal antibodies to human interleukin-4

摘要

PCT No. PCT/US93/01301 Sec. 371 Date Aug. 16, 1994 Sec. 102(e) Date Aug. 16, 1994 PCT Filed Feb. 18, 1993 PCT Pub. No. WO93/17106 PCT Pub. Date Sep. 2, 1993Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal antibodies and complementarity determining regions from such DNAs; and kits and methods for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.