PROCESS FOR THE PREPARATION OF 2-// (2-PYRIDINYL)-METHYL/-SULFYNYL/-1H-BENZIMIDAZOLES AND NOVEL COMPOUNDS OF USE FOR SUCH PURPOSE

摘要

2-[[(2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole derivatives of general formula (V) wherein R2 represents H, OCH3, OCHF2 or CF3, R3 represents H, CH3 or OCH3, R4 represents H, OCH3, OCH2CF3, halo or nitro, R5 represents H, CH3 or OCH3, and n is 0 or 1, or salts thereof, are prepared by a new process proceeding via novel intermediates of general formulae (I), (II), (III) and (Va) wherein R1 represents branched or straight C1-8-alkyl, C3-8-cycloalkyl, aryl, aralkyl having 1-8 C-atoms in the alkyl moiety, or a 5- or 6-membered heterocyclic group having one, two or three hetero atoms selected from nitrogen, sulfur and oxygen in the heterocyclic ring. The compounds of formula (V) are biologically active and/or may be used as intermediates in the synthesis of biologically active compounds.