PROCESS FOR PREPARATION OF PURIFIED NUCLEIC-ACID SEQUENCE CORRESPONDING TO HUMAN GP39, OF CORRESPONDING SOLUBLE GP39, AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, AND PROMOTING OF B-CELL PROLIFERATION

摘要

The present invention relates to a process for the preparation of a purified gp39-corresponding purified nucleic acid sequence in a manner that would form L234F, L235E and G237A mutations in the CD40-Igimmoglobulin genome. supplemented by a chain reaction, positive clones are selected by hybridization with primers containing primers containing the above-mentioned sequences corresponding to the above-mentioned sequence, and the desired female cleavage sequence is selected by immunoprecipitation from apositive clones. The present invention relates to the preparation of a killed gp39 protein of the corresponding amino acid sequence and to pharmaceutical compositions containing it, and to the in vitro amplification of B cell proliferation using the killed gp39 protein produced. ŕ