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TREATMENT OF PROSTATE CANCER BY USE OF AN ANTIANDROGEN AND A NON-ADRENAL SEX-STEROID FORMATION INHIBITOR
TREATMENT OF PROSTATE CANCER BY USE OF AN ANTIANDROGEN AND A NON-ADRENAL SEX-STEROID FORMATION INHIBITOR
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机译:使用抗雄激素和非肾上腺性类固醇形成抑制剂治疗前列腺癌
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摘要
A method of treatment of androgen-related diseases such as prostate cancer in susceptible male animals, including humans, comprises administering novel antiandrogens and/or novel sex steroid biosynthesis inhibitors as part of a combination therapy. Sex steroid biosynthesis inhibitors, especially those capable of inhibiting conversion of dehydroepiandrosterone (DHEA) or 4-androstenedione ( DELTA 4-dione) to natural sex steroida (and testosterone into dihydrotestosterone) in peripheral tissues, are used in combination with antiandrogens usually after blockade of testicular hormonal secretions. Antiestrogens can also be part of the combination therapy. Pharmaceutical compositions and two, three, four and five component kits are useful for such combination treatment.
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