PHARMACEUTICAL COMPOSITIONS CONTAINING NSAID AND BILE ACIDS

摘要

Non-steroidal anti-inflammatory drugs, such asindomethacin, and other pharmaceutically activecompounds, are formulated with bile acids or their saltsand conjugates. Bile acids previously proposed for use insuch formulations have placed an unacceptable toxic loadon the liver and/or cells of the gastrointestinal tract,causing abnormal liver function or cell erosion. In thisinvention, the bile acid is a low detergent bile acid,such as ursodeoxycholate. Stabilization of the bileacid pool results in enhanced and predictableenterohepatic recycling of NSAIDs (and other drugs) anda reduced risk of toxicity.