New antifungals homochiral compounds for the preparation of ketoconazole, terconazole and related process for their manufacture and use thereof.

摘要

NEW COMPOUNDS FOR PREPARING homochiral ketoconazole, terconazol and Antifungal RELATED METHOD FOR MANUFACTURING AND USE THEREOF. The present invention relates to novel compounds homochiral which are intermediates in the preparation of various azole antifungals Formula V enantiomerically pure form, wherein Ar is a phenyl group or substituted phenyl, SO THE GROUP substituted phenyl may contain one to three substituents each WHICH CAN BE INDEPENDENTLY fluorine, chlorine, bromine, (C1-C4) -alkyl or (C1-C4) -ALQUILOXI; Y is a group CH or a nitrogen atom; Z is a group COCH3, CH (CH3) 2 O Similarly, the present invention relates to OWN COMPOUNDS (+) - terconazole and (-) - terconazole. SUCH ACTIVITY compounds have antifungal and antibacterial, MAY BE USED IN THERAPY FOR HUMAN AND VETERINARY.