Process for the production of N-beta- g (b) -hidroxialquil-tri-n-1,4,7,10-tetraazacyclo carboxyalkyl-dodecane and n-beta- g (b) -hidroxialquil-tri- n-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane and its metal complexes.

摘要

PROCESS FOR THE PREPARATION OF DERIVATIVES N ALKYL ANO AND DERIVATIVES N QUIL TALICOS OF FORMULA GENERAL (I) wherein R1 is a) 1 (A), N MEAN FIGURES 2 O 3, where is optionally present hydroxy moiety OR GROUPS CARBOXI in protected form, by reacting 1,4,7,10 tetraazacyclododecane 1,4,8,11 or their salts in the presence of a base with an epoxy of formula (II) in a polar solvent or without solvent in TEMPERATURES FROM 0 presence of a base, with a compound of formula (III).