CLONING AND CHARACTERIZING OMEGA-INTERFERON AND RELATED GENES

摘要

The present invention provides new interferonpolypeptides of Type 1 coded for by the cDNA inserts of plasmidsP9A2 and E76E9 (deposited at the DSM within E.coli HB101 under thenumbers DSM 3003 and 3004 respectively), further interferonpolypeptides coded for by sequences which will hybridise with thesequences corresponding to the interferon-coding sequences ofplasmids P9A2 and E76E9 or degenerate variations thereof understringent hybridisation conditions suitable for detecting about85% or higher homology, and N-glycosylated or other derivativesthereof with interferon activity. Such interferons have beendesignated omega interferons and are useful in treatments in whichknown interferons have been used, for example, herpes, rhinovirusand AIDS infections as well as certain cancers.