Provided are hybridomas for producing monoclonalantibodies against acetylated lysine residues of rbSt. Theantibodies are specific to the presence of at least a singleacetylated lysine in a protein and can differentiate between.alpha.-acetyl and .epsilon.-acetyl lysine as free amino acids. The inventionprovides a guantitative and efficient test for acetylatedimpurities in recombinant proteins prepared using E.coli as thehost.
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