SEMI-SYNTHETIC GLYCOSAMINOGLYCANS WITH HEPARIN OR HEPARAN STRUCTURE OF amp;#150;-L-IDURONIC-2-SULFATE ACID MODIFIED IN POSITION 2

摘要

The synthesis of new semi-synthetic glycosaminoglycanswith heparin or heparan structure of .alpha.-L-iduronic-2-O-sulfate acid modified in position 2 is described in whichthe sulfate group is, entirely or in part, substituted witha nucleophilic radical. These new semi-syntheticglycosaminoglycans of general formulahave good pharmaceutical properties in that they may alsobe absorbed orally and have good anti-thrombotic activityaccompanied by low risk of haemorrhage and reducedanti-coagulating activity.