SEMI-SYNTHETIC GLYCOSAMINOGLYCANS WITH HEPARIN OR HEPARAN STRUCTURE OF ALPHA-L-IDURONIC-2-O-SULFATE ACID MODIFIED IN POSITION 2

摘要

The present invention relates to the synthesis of novel semi-synthetic glycosaminoglycans having a heparin or heparan structure of a 2-L-modified α-L-iduronic-2-0-sulfuric acid. Synthetic glycosaminoglycans are those in which the sulfate group is substituted, in whole or in part, with nucleophilic radicals.;These novel semi-half glycosaminoglycans with formula (IV) have good pharmaceutical properties that can absorb the case, and are good anti-thrombotic agents that reduce the risk of bleeding and reduce anticoagulant activity. has anti-thrombotic activity.