IN VIVO MODIFICATION OF GALACTOMANNANS IN GUAR BY EXPRESSION OF UDP-GALACTOSE EPIMERASE ANTISENSE RNA

摘要

An in vivo modification process is described. The process affects the mannose-to-galactose ratio of either an organism (or part thereof) capable ofproducing a mannose/galactose containing compound or of a mannose/galactosecontaining compound thereof. The in vivo modification process comprisesexpressing a nucleotide sequence that has an effect on: (a) the mannose-to-galactose ratio of mannose and galactose components of a mannose/galactosecontaining compound; and/or (b) the mannose-to-galactose ratio of mannose andgalactose precursors for a mannose/galactose containing compound; and whereinthe nucleotide sequence is antisense to at least a part of the gene for a UDP-galactose epimerase enzyme.