CARBOXY PIPERIDYLACETAMIDE TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES (FARNESYL PROTEIN TRANSFERASE INHIBITORS)

摘要

Compounds of formula (I) useful for inhibiting Ras function and thereforeinhibiting or treating the abnormal growth of cells (farnesyl proteintransferase inhibitors) are disclosed or an N-oxide thereof, or apharmaceutically acceptable salt or solvate thereof, wherein: Q and T areindependently selected from halo; W and V are independently selected from Hand halo, provided that at least one of W and V is H; R1 is H or alkyl; Xrepresents N, CH, or C when the double bond is present at the C-11 position; Ris -OR3, -NR3R4 or -SR3; and R3 and R4 are independently selected from thegroup consisting of H, alkyl, arylalkyl, substituted arylalkyl,heteroarylalkyl and substituted heteroarylalkyl.