Carboxy piperidylacetamide tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases (farnesyl protein transferase inhibitors)

摘要

Compounds of the following formula useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells are disclosed:ceutically acceptable salt or solvate thereof, wherein: Q and T are independently selected from halo; W and V are independently selected from H and halo, provided that at least one of W and V is H; R1 is H or alkyl; X represents N, CH, or C when the double bond is present at the C-11 position; R is -OR3,-NR3R4or -SR3; and R3 and R4 are independently selected form the group consisting of H, alkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl and substituted heteroarylalkyl.