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Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus2-mediated transgene expression
Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus2-mediated transgene expression
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机译:细胞蛋白酪氨酸磷酸化在腺相关病毒2介导的转基因表达中的作用
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摘要
The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells by inhibiting the leading strand viral DNA synthesis. More particularly, the present invention demonstrates that D-BP is phosphorylated by EGF-R protein tyrosine kinase. Methods of increasing transcription and promoting replication of transgenes exploiting this information are disclosed therein.
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