USE OF A CARDIAC PURINOCEPTOR TO EFFECT CELLULAR GLUCOSE UPTAKE

摘要

The invention provides a method of determining whether a compound is a glucose uptake modulator, including use of a cell comprising an isolated nucleic acid encoding a glucose uptake-enhancing myocardial purinoceptor. The invention also includes a method of enhancing glucose uptake into a cell such as a mammalian cardiac myocyte, a method of affecting the activity of an intracellular enzyme, and pharmaceutical compositions for use in these methods. The method of enhancing glucose uptake into a cell may be used to minimize ischemic cardiac damage, such as that attributable to angina pectoris, chronic stable angina, unstable angina, post-myocardial infarction angina, myocardial infarction, cardiac arrhythmia, coronary artery disease, diabetes mellitus, and cardiac ischemia attributable to schock, stress, or exertion.