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Use of a cardiac purinoceptor to effect cellular glucose uptake
Use of a cardiac purinoceptor to effect cellular glucose uptake
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机译:心脏嘌呤受体在细胞葡萄糖摄取中的应用
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摘要
The invention provides a method of determining whether a compound is a glucose uptake modulator, including use of a cell comprising an isolated nucleic acid encoding a glucose uptake-enhancing myocardial purinoceptor. The invention also includes a method of enhancing glucose uptake into a cell such as a mammalian cardiac myocyte, a method of affecting the activity of an intracellular enzyme, and pharmaceutical compositions for use in these methods. The method of enhancing glucose uptake into a cell may be used to minimize ischemic cardiac damage, such as that attributable to angina pectoris, chronic stable angina, unstable angina, post-myocardial infarction angina, myocardial infarction, cardiac arrhythmia, coronary artery disease, diabetes mellitus, and cardiac ischemia attributable to schock, stress, or exertion.
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