Production method of phospholipid nanocapsules having excellent long-term stability

摘要

The present invention relates to a method for preparing a phospholipid nanocapsule having excellent long-term stability. More specifically, the present invention relates to a method for producing a phospholipid nanocapsule which comprises 0.1 to 10% by weight of a hydrophobic substance selected from the group consisting of vitamin A, vitamin E and squalane, And 0.5 to 4% by weight of a nonionic surfactant having a hydrophilic-hydrophobic quantitative HBL value of 8 to 25 and having a polyethylene oxide chain and a hydrophilic-hydrophobic property, The present invention relates to a method for producing a phospholipid nanocapsule excellent in long-term stability by ultrasonic treatment of an emulsion. The phospholipid nanocapsules prepared by the present method showed a uniform size distribution with a size of 100 to 300 nm.