METHOD OF CIPROFLOXACIN TABLETS PREPARING

摘要

FIELD: medicinal industry, pharmacy. SUBSTANCE: invention relates to ready drugs. Corn starch and microcrystalline cellulose are mixed, obtained mixture is wetted with water and ciprofloxacin hydrochloride is added. Obtained mass is wetted again and subjected for wet granulation, drying, dry granulation followed by powdering with a mixture consisting of crosspovidone, aerosil, magnesium stearate, corn starch and microcrystalline cellulose and tabletting. At the first wetting water is added in the amount 10.0-12.0 wt. -% of the charge mass and at the repeated wetting, in the amount 3.0-5.0 wt. -% up to preparing the solid curdy-like mass. For preparing a mixture of powder-like components 7.0-8.5 wt.-% of corn starch and 3.6-4.4 wt.-% of microcrystalline cellulose are used and for powdering - 1.8-2.0 wt. -% and 3.1-3.5 wt.-%, respectively. Tablet strength is 5-7 kg in the process of making, decomposition time - 6-7 min. EFFECT: improved method of preparing, improved quality of tablets. 3 cl, 1 ex