2-(2-AMINO-1,6-DIHYDRO-6-OXOPURIN-9-YL)METOXY-3-HYDROXY- 1-PROPANYL-L-VALINATE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD OF PREPARING THEREOF, PHARMACEUTICAL COMPOSITION AND HYDROXY AND/OR AMINO PROTECTED 2-(2- AMINO-1,6-DIHYDRO-6-OXOPYRIN-9-YL) METHOXY-3-HYDROXY-1- PROPANYL-L-VALINATE

摘要

FIELD: pharmaceutical industry. SUBSTANCE: described are new compounds such as 2-(2- amino-1,6-dihydro-6-oxopurin-9-yl)methoxy-3-hydroxy-1- propanyl-L- valinate or pharmaceutically acceptable salt thereof in the form of its (R)-or (S)-diastereomers or in the form of mixtures of both diastremers. They are valuable antiviral agents with improved absorbability. Also described is pharmaceutical composition based on compounds of formula I, hydroxy and/or aminoprotected 2- (2-amino-1,6-dihydro-6-oxopurin-9-yl) methoxy-3-hydroxy- 1-propanyl-L-valinate. EFFECT: improved properties of the pharmaceutical composition. 16 cl, 11 ex