Reducing neurological damage in Gram positive bacterial meningitis using a protein kinase inhibitor

摘要

The use of protein kinase inhibitors (I), specifically substituted cinnamic acid derivatives, is claimed for blockade of the microglial ERK (abbreviation not defined) system and for reducing damage to the central nervous system (CNS) caused by Gram-positive bacterial infections. An Independent claim relates to a pharmaceutical composition for treating meningitis, containing (I) and optionally conventional pharmaceutical auxiliaries, carriers and/or additives.