Mono sig acid derivatives of the peptides leu - phe - ala and ala - leu - phe and their use in the recognition and destruction of tumor cells and virus-infected cells

摘要

The monoacetic derivatives of tripeptides leucine-phenylalanine-alanine and alanine-leucine-phenylalanine are effective in activating NK lymphocytes to identify and destroy directly, that is without any interference by the immune system, aberrant tumour cells, metastatic cells, viruses and virus-carrying cells, so as to result in an "active immunotherapy". The invention also concerns the use of the said monoacetyl-tripeptides in the treatment and prophylaxis of cancer and viral diseases, as well as the pharmaceutical compositions containing one or both of the said compounds, together wit a suitable carrier and, optionally, with other pharmaceutically active substances.