Expression of the INSL4 gene in human embryonic bone tissue and ligaments,

摘要

An INSL4 gene characterized in that it is expressed in human embryonic bone tissue and ligaments, is new. Independent claims are also included for the following: (1) EPIL 1, 2 and 3 encoded by INSL4; (2) a method to detect or identify the localization and/or level of a specific EPIL 1, 2 or 3, or INSL4, or their homologues or variants in a biological sample of bone tissue or ligaments, for the diagnosis of a pathology associated with abnormal EPIL 1, 2 or 3 or INSL4; (3) kits for (2); (4) methods to mark cells of bone tissue and/or ligaments; (5) a method of identifying chemical or biochemical compositions capable of modulating differentiation, regeneration and/or proliferation of human and/or animals bone tissue and/or ligament cells; and (6) a chemical or biochemical composition identified by (5).