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Methods for detecting calpain activation and identifying calpain inhibitors
Methods for detecting calpain activation and identifying calpain inhibitors
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机译:检测钙蛋白酶激活和鉴定钙蛋白酶抑制剂的方法
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摘要
The invention provides methods for detecting calpain activation by measuring levels of calpain-generated spectrin BDPs using antibodies that specifically bind to these spectrin BDPs, but not intact spectrin, or spectrin BDPs generated by other proteases. Also included in the invention are kits for diagnosing diseases associated with increased levels of calpain activation, and methods for screening for effective therapeutics for these diseases.
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