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Adenoviral vectors for gene therapy containing deletions in the adenoviral genome
Adenoviral vectors for gene therapy containing deletions in the adenoviral genome
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机译:用于基因治疗的腺病毒载体,包含腺病毒基因组中的缺失
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摘要
Adenoviral vectors which contain deletions of the early regions and/or late genes provide efficient delivery and expression of foreign nucleic acids of interest to patients. These vectors have a particular use in the treatment of cystic fibrosis patients. Furthermore, PAV vectors provide for a second generation of adenoviral vectors that contain the 5' ITR's, the packaging signal and the E1A enhancer. Other adenoviral vectors contain a deletion of the E1 region or a deletion of E4 but retain orf3 or orf6, and can either retain or delete the E3 region.
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