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DNA molecules encoding PDGF molecules having protease resistant basic cleavage sites
DNA molecules encoding PDGF molecules having protease resistant basic cleavage sites
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机译:编码具有蛋白酶抗性基本切割位点的PDGF分子的DNA分子
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摘要
PDGF B-chain polypeptides characterized by the substitution or deletion of a lysine or arginine residue at position 27, 28, 32, 79, 80 or 81 of native B-chain are disclosed. Also disclosed are PDGF-like proteins containing the B-chain polypeptides. The polypeptides and proteins may be produced through the use of cultured cells transfected or transformed to express DNA molecules that encode the polypeptides. The PDGF-like proteins are useful as components of cell culture media and for accelerating the healing of wounds.
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