Escherichia coli K-12 strains for production of recombinant proteins

摘要

Novel Escherichia coli K-12 strains comprising diminished catechol production and/or orotate phosphoribosyltransferase activity levels of at least about 30 units, and methods for the use of such novel Escherichia coli K-12 strains in increasing the production of heterologous proteins therein are disclosed.