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Method for detecting a predisposition to susceptibility to toxic effects of drugs and poisons
Method for detecting a predisposition to susceptibility to toxic effects of drugs and poisons
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机译:检测药物和毒药的毒性作用易感性的方法
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摘要
The present invention relates to methods for diagnosis of susceptibility to neurotoxicity or the pathological effects of neurotoxicity based on detection of a genetic marker in an individual. The present invention is directed generally to methods and associated compositions and kits for detecting the presence of arylsulfatase A (ASA) pseudodeficiency (PD) mutations in humans. Detection of these mutations has been surprisingly found to be a strong indicator for susceptibility to neurotoxicity and/or susceptibility to toxicant's pathological effects, as well as an important marker in evaluating the likelihood of metachromatic leukodystrophy (MLD).
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