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Use of matrices comprising liquids and light absorbing particles for analysis of microorganisms by laser desorption mass spectrometry
Use of matrices comprising liquids and light absorbing particles for analysis of microorganisms by laser desorption mass spectrometry
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机译:包含液体和吸光颗粒的基质在通过激光解吸质谱分析微生物中的用途
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摘要
The present invention is directed to a method of using a liquid matrix containing a black body light absorbing powder to facilitate the analysis of biomarkers from representative microorganisms by laser desorption mass spectrometry. Both an IR laser (1064 nm) and a UV laser (337 nm) were shown to be compatible and both time-of-flight and Fourier- transform mass analyzer were used. In the present implementation gram negative and gram positive bacteria were suspended in a methanol:chloroform solution and added to a cobalt/glycerol matrix, S/N, sensitivity and sampling time are greatly enhanced for polar lipid biomarkers.
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