1,2,4-triazolo4,3-cquinazolin-3-ones and 1,2,4-triazolo4,3- c quinazolin-3-thiones

摘要

The present invention encompasses structures of the Formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: X is oxygen, H.sub.2, or sulfur;PPY is oxygen or sulfur; P PW is alkyl, arylalkyl, or heteroarylalkyl, each of which is optionally substituted; orPPW is aryl or heteroaryl; ##STR2## wherein: Z.sub.1, Z.sub.2, Z.sub.3, and Z.sub.4 independently represent nitrogen or C--R.sub.a, wherePP each R.sub.a independently is hydrogen, an inorganic substitutent or an optionally substituted aromatic group;PPn is 1, 2 or 3; andP PR.sub.b is hydrogen, alkyl, or an optionally substituted aromatic group,PPwhich compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.