Their use for modulating cellular proliferation and oligonucleotides derived from untranslated regions of the housekeeping gene

摘要

The present invention relates to oligonucleotides having the sequence of an untranslated region (UTR) of mRNA from a housekeeping gene and which can modulate the tumorigenicity of neoplastic cells. The present invention further provides pharmaceutical compositions and methods of inhibiting the growth of neoplastic/malignant cells in a mammal with oligonucleotides having sequences of untranslated regions of the mRNA of housekeeping genes. In a preferred embodiment the UTR is the 3'-UTR and the housekeeping gene is ribonucleotide reductase and its regulatory sequences.