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OLIGONUCLEOTIDES FROM THE UNTRANSLATED REGIONS OF HOUSEKEEPING GENES AND METHODS OF USING SAME TO MODULATE CELL GROWTH
OLIGONUCLEOTIDES FROM THE UNTRANSLATED REGIONS OF HOUSEKEEPING GENES AND METHODS OF USING SAME TO MODULATE CELL GROWTH
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机译:来自家庭基因的未翻译区的寡核苷酸和使用相同的方法调节细胞生长的方法
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摘要
The present invention relates to oligonucleotides having the sequence of an untranslated region (UTR) of mRNA from a housekeeping gene and which can modulate the tumorigenicity of neoplastic cells. The present invention further provides pharmaceutical compositions and methods of inhibiting the growth of neoplastic/malignant cells in a mammal with oligonucleotides having sequences of untranslated regions of the mRNA of housekeeping genes. In a preferred embodiment the UTR is the 3'-UTR and the housekeeping gene is ribonucleotide reductase and its regulatory sequences.
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