首页> 外国专利> 5,7-dihydro-3- 2- {1-Benzyl-piperidin-4-yl} ethyl -6H- pyrrolo - 4,5-f -1,2- benzisoxazole-6-production method of and intermediates

5,7-dihydro-3- 2- {1-Benzyl-piperidin-4-yl} ethyl -6H- pyrrolo - 4,5-f -1,2- benzisoxazole-6-production method of and intermediates

机译:5,7-二氢-3- [2- {1-苄基哌啶-4-基}乙基] -6H-吡咯烷-[4,5-f] -1,1,2-苯并异恶唑-6的生产方法及中间体

摘要

(57) Abstract As for this invention, being something regarding the production manner of the chemical compound which is displayed with formula (i), i) formula (vii) (the inside R of formula3 R4 (as for R4 R5 - C (=O), R5 OC (=O) or from R5 SO2 is chosen in this manner, (as for R5 (C1 - C6) alkyls or (C6 - C10) aryls (C1 - C6) alkyls))Or the benzyl is) chemical compound, under base existing heating at high temperature, however R3 of the product which is obtained in case of R4, that product the mineral acid aqueous solution is treated at II) furthermore high temperature, continuously III) II) a) under existing of the base benzyl conversion medicine and treatment or b) benzaldehyde treating is included the product, under existing of the reducing agent and the Acid.
机译:(57)<摘要>关于本发明,涉及式(i),i),式(vii)(式 3 的R内侧)所示的化合物的制造方式R 4 (对于R 4 R 5 -C(= O),R 5 OC(= O )或以这种方式从R 5 SO 2 中选择(对于R 5 (C 1 - C 6 )烷基或(C 6 -C 10 )芳基(C 1 -C 6 )烷基))或苄基是)化合物,在高温下存在碱的条件下加热,但是在R 4情况下获得的产物的R 3 ,将产物无机酸水溶液在II)进一步高温下连续处理III)II)a)在基础苄基转化药物存在下进行处理,或b)苯甲醛处理包括在该产品存在下还原剂和酸。

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