BENZYLAMINE Derivatives of amido - and aminosustituidos, method for its preparation and Method for treating or Preventing a Physiological Disorder, Medicine that containsUse of such compounds for preparing Medicines, acilado prodrug and Pharmaceutical composition containing them

摘要

Compounds including formula (I),One of x1, X2 and X3 is formula (II),The other members of groups x1, X2 and X3 are hydrogen; q is nitrogen or oxygen; D is tar in the lower thyroid chain with 1 to 6 carbon atoms or may combine with G to form a ring; E is or H2; or R is 0 or 1; G is the lower tar. Hip joint or branch with 1 to 6 carbon atoms, arilo replaced by halogen, tar in the lower rectal chain, or branch with 1 to 6 decarbono atoms, from 2 -.3-O 4-pyridine, 2-pyridine, 2-O 3-tienilo, 2-pyridine, 2-3- or 4-quinolyl, 1-, 3- or 4-isoquinolyl, 2-quinoxalyl, 3- or 4-cinolyl, heteroaryl substituted by halogen, hydroxy, branched or straight chain lower alkyl with 1 to 6 carbon atoms, alkoxy straight or branched lower chain with 1 to 6 carbon atoms; or is attached to D to form a ring; Ar is a group aryl preferably selected from the group consisting of phenyl, 2- 3- or 4-pyridyl, 2- or 3-thienyl, 2-,4-O 5-piriminal, each optional single mass, or discustitude containing halogen, hydroxyl or lower rectal chain tar or derivatives with 1 to 6 carbon atoms; B is sulfur, oxygen, n (R5) or C (R5) (R6);N is 1, 2 or 3; m is 2, 3 or 4; a and T are the same or different, representing the branch of hydrogen, halogen, hydrogen Xi, decaden subrectal tar or 1 to 6 carbon atoms, or the branch of subrectal oxygen or 1 to 6 carbon atoms; R1 and R2 are different, representing hydrogen, Or a base chain or branch pitch having 1 to 6 carbon atoms; R3 and R4 are equal to or different; and