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Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
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机译:三环二氮杂血管加压素拮抗剂和催产素拮抗剂
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摘要
Tricyclic diazepine derivs. of formula (I) and their pharmaceutically acceptable salts, esters and pro-drugs are new. Y = (CH2)n, CH(1-3 C alkyl) or CO; AB = (CH2)mN(R3) or N(R3)(CH2)m ; n = 0-2; m = 1-2; provided that when Y = (CH2)n and n = 2, m may also be 0, and when n = 0, m may also be 3, provided also that when Y = (CH2)n and n = 2, m is not 2; R3 = COAr; Ar = substd. phenyl; opt. N-substd. indole; or opt. substd. furan, thiophene or pyrrole; D, E, F = C or N, any C atoms being opt. substd.; Z is such that the ring contg. it = opt. substd. fused phenyl; 5-membered aromatic, opt. satd. ring contg. one of O, N and S; 6-membered aromatic, opt. satd. ring contg. one N; 5- or 6-membered aromatic, opt. satd. ring contg. two N; or 5-membered aromatic, opt. satd. ring contg. one N, and either one O or one S; the heterocyclic rings are opt. substd.
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机译:三环二氮杂pine衍生物。式(I)的化合物及其药学上可接受的盐,酯和前药是新的。 Y =(CH 2)n,CH(1-3 C烷基)或CO; AB =(CH2)mN(R3)或N(R3)(CH2)m; n = 0-2; m = 1-2;假设当Y =(CH2)n并且n = 2时,m也可以是0,并且当n = 0时,m也可以是3,还可以当Y =(CH2)n并且n = 2时,m不是2; R3 = COAr; Ar =被取代。苯基选择。 N-取代吲哚或选择取代呋喃,噻吩或吡咯; D,E,F = C或N,可以选择任何C原子。 ; Z是这样的环连续。它=选择。取代稠苯基5元芳烃,可选。坐下环续O,N和S之一;六元芳烃,可选。坐下环续一N; 5元或6元芳烃,可选。坐下环续两个N或5元芳香族(可选)。坐下环续一个N,一个O或一个S;杂环是可选的。取代
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