Erythromycin a derivative, pharmaceutical composition, antibacterial preparation, process for treating a bacteriologically infectious disease, and use of the erythromycin derivative a or a pharmaceutically acceptable salt thereof.

摘要

"ERYTHROMYCIN A DERIVATIVE, PHARMACEUTICAL COMPOSITION A represented by formula (I): [where n is an integer from 1 to 4, R ^ 1 ^ is a group represented by the formula: a group represented by the formula: a pyridylacetyl group, a 1,2-bis (ethoxycarbonyl) vinyl group, R ^ 2 ^ is the same group as defined for R ^ 1 ^, a hydrogen atom, an alkyl group with 1 to 5 carbon atoms, an alkanoyl group with 2 to 6 carbon atoms or an alkoxycarbonyl group with 2 to 6 carbon atoms, R ^ 1 ^ and R ^ 2 ^ together form a group of formula: = CH-R ^ 14 ^, or R ^ 1 ^ and R ^ 2 ^, together with the nitrogen atom to which they are attached, form a group represented by the formula: R ^ 15 ^ and R ^ 16 ^ are each a hydrogen atom or, when W is a carbon atom, R ^ 15 ^ and R ^ 16 ^, fixed together, form a benzene ring or a naphthalene ring, R ^ 3 ^ is a hydrogen atom, a cinamyl group, R ^ 4 ^ is a hydrogen atom, a group acetyl, a ethylsuccinyl group or a nicotinoil group, A is a group represented by the formula alkyl group with 1 to 5 carbon atoms] or a pharmaceutically acceptable salt thereof, it has a strong antibacterial activity not only against known bacteria sensitive to erythromycin, but also against bacteria resistant to erythromycin.