Process that allows to reduce the frequency of intra-or intermolecular homologous recombination events between nucleic acids, process for the preparation of defective recombinant adenoviruses, and defective recombinant adenoviruses

摘要

"PROCESS THAT ALLOWS TO REDUCE THE FREQUENCY OF INTRA- OR INTERMOLECULAR HOMOLOGICAL RECOMBINATION EVENTS BETWEEN THE CHROMOSHEMIC ACID OF A CELL, WHICH CODES FOR THE COMPLEMENTATION FUNCTIONS OF A DEFECTIVE ADENOVIRUS, WHICH IS COMBINATING, OOMICOUS, COMBINATION PROCESS OF PREPARING DEFECTIVE RECOMBINANT ADENOVIRUSES, DEFECTIVE RECOMBINANT ADENOVIRUS AND CELL THAT UNDERSTANDS A DEFECTIVE ADENOVIRUS. " The present invention relates to a process that makes it possible to reduce the recombination events between nucleic acids. It also refers to the application of this process in the production of defective viruses not contaminated by replicative particles. The invention also relates to new viral constructs.