Composition for the treatment of respiratory and skin diseases, comprising at least one leukotriene antagonist and at least one antihistamine

摘要

Invention Patent: B "COMPOSITION FOR THE TREATMENT OF RESPIRATORY AND SKIN DISEASES, UNDERSTANDING AT LEAST ONE LEUCOTRIEN ANTAGONIST AND AT LEAST ONE ANTI-HISTAMINE" D. Pharmaceutical composition usable in the treatment of sneezing, runny nose itching, nasal congestion, redness of the eye, watery eyes, itchy ears or palate, shortness of breath, inflammation of the bronchial mucosa, reduced forced expiratory volume in one second (FEV ~ 1 ~) , coughs, rashes, itchy skin, headaches, and pains associated with seasonal allergic rhinitis, perennial allergic rhinitis, common colds, otitis, sinusitis, allergy, asthma, allergic asthma and / or inflammation, in a mammalian organism in need this treatment. The composition comprises i) an effective amount of at least one leukotriene antagonist selected from a) a montelukast, b) acid 1 - (((R) - (3- (2- (6,7-difluor-2-quinolinyl) ethenyl) phenyl) -3- (2- (2-hydroxy-2-propyl) phenyl) thio) methylcyclopropanoacetic; c) 1 - (((1 (R) -3- (3- (2-2,3- dichlorothieno [3,2-b] pyridin-5-yl) (E) -ethyl) phenyl) -3- (2- (1-hydroxy-1-methylethyl) phenyl) propyl) thio) methyl) acetic cyclopropane; d) pranlukast; or e) zafirlukast; or f) [2 - [[2- (4-tert-butyl-2-thiazolyl) -5-benzofuranyl] oxymethyl] phenyl] acetic acid; or a pharmaceutically acceptable salt thereof, in mixture with ii) an effective amount of at least one antihistamine which is descarboethoxyloratidine, cetirizine, fexofenadine, ebastine, astemizole, norastemizole, epinastine, efletirizine or a pharmaceutically acceptable salt thereof.