Compound or a pharmacologically acceptable salt or derivative thereof, and anti-inflammatory drugs, for the prevention or treatment of chronic rheumatism, and for the prevention or treatment of osteoarthritis

摘要

"COMPOUND OR A SALT, DERIVED OR SOLVATE FROM THIS PHARMACOLOGICALLY ACCEPTABLE, USE OF THE SAME, AND, ANTI-INFLAMMATORY MEDICINES, FOR THE PREVENTION OR TREATMENT OF CHRONIC RHEUMATISM, FOR THE PREVENTION OR TREATMENT OF OSTEOARTHRITIS TREATMENT, FOR THE TREATMENT OF THE TREATED TREATMENT AND FOR USE AS AN ANALGESIC ". [Objective] To provide a compound that has inhibitory activity against the production of inflammatory cytokines. [Means For Solution] A compound of formula (I), or a pharmacologically acceptable salt or derivative thereof. [where, A: single bond, oxygen, sulfur, CO, SO, SO ~ 2 ~, C (R ^ 9 ^) (R ^ 10 ^) [R ^ 9 ^, R ^ 10 ^: H, OH, halogen, alkyl], N (R ^ 11 ^), C = NOR ^ 11 ^ [R ^ 11 ^: H, alkyl]; D: single bond, C (R ^ 12 ^) (R ^ 13 ^) [R ^ 12 ^, R ^ 13 ^: H, OH, halogen, alkyl]; R¹: unsubstituted or substituted pyridyl; R²: unsubstituted or substituted phenyl; R³: halogen, alkyl, haloalkyl, alkoxy, haloalkoxy; R ^ 4 ^, R ^ 5 ^, R ^ 6 ^, R ^ 7 ^ and R ^ 8 ^: H, alkyl; k: 0 to 3; m: 1, 2]