Compounds derived from 4 - (aryl (heteroaryl) - 3 - (pyrrole or imidazole - il - 2 - 5 - ol) methylene) - indole - 3 - ona replaced inhibitors or modulators of the Protein quinansas (JNK), its Salts,Intermediates and Pharmaceutical compositions useful in the Treatment or control of inflammatory diseases such as Arthritis reumatoride.

摘要

Compounds derived from 4 - (aryl (heteroaryl) - 3 - (2 - or imidazole sirrol - il - 5 - il) methylene) - indole - 3 - ona formula and its Salts where R2, R3,X and a are as described in the specification, inhibit or modulate Protein Kinases, including protein kinase JNK and are useful as anti-inflammatory agents.Particularly in the treatment of rheumatoid arthritis. The pharmaceutical compositions and the intermediate Compound of formula.