INCLUSION COMPLEXES OF NIMESULIDE SALTS OF ALKALI METALS AND ALKALINE EARTH METALS WITH CYCLODEXTRINS, PROCESS OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF

摘要

Salts of Formula I wherein A is an alkali or alkaline earth ion form inclusion complexes and cyclodextrins and cyclodextrin derivatives at a molar ratio of salt to cyclodextrin of 1: 1 or 1: 2. Suitable are alpha, .beta. or gamma-cyclodextrins and / or alkyl or hydroxyalkyl derivatives of cyclodextrin, such as nimesulide sodium salt, In the preparation of inclusion complexes, nimesulide salts are reacted in the presence of water with cyclodextrins at pH 7 to 9.5. The complexes formed are freeze-dried, spray-dried, low temperature vacuum evaporation, vacuum drying. The pharmaceutical composition comprises the inclusion complexes as active ingredient.ŕ